Identification of Potential Tumor Differentiation Factor (TDF) Receptor from Steroid-responsive and Steroid-resistant Breast Cancer Cells*

Identification of a Potential Tumor Differentiation Factor (tdf) Receptor from Steroid-responsive and Steroid-resistant Breast Cancer Cells

IDENTIFICATION OF A POTENTIAL TUMOR DIFFERENTIATION FACTOR (TDF) RECEPTOR FROM STEROID-RESPONSIVE AND STEROID-RESISTANT BREAST CANCER CELLS Izabela Sokolowska, Alisa G. Woods, Mary Ann Gawinowicz, Urmi Roy and Costel C. Darie From Department of Chemistry & Biomolecular Science, Biochemistry & Proteomics Group, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5810 and Protein Core Faci...

Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action.

Under conditions of short-term hormone deprivation, epidermal growth factor (EGF) induces DNA synthesis, cytoskeletal changes, and Src activation in MCF-7 and LNCaP cells. These effects are drastically inhibited by pure estradiol or androgen antagonists, implicating a role of the steroid receptors in these findings. Interestingly, EGF triggers rapid association of Src with androgen receptor (AR...

Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer

Steroid hormone-responsive secondary factor X deficiency.

disease and/or platelet activation, and may not participate directly in pathogenesis. We conclude that raised sP-selectin indicates a poor prognosis among patients with peripheral artery disease. The wide range of values means that this marker alone is unlikely to be of value in defining the risk of disease progression in any individual subject. However, it may be useful as part of a panel of m...

Tumor Differentiation Factor (TDF) and its Receptor (TDF-R): Is TDF-R an Inducible Complex with Multiple Docking Sites?

Tumor Differentiation Factor (TDF) is a protein produced by the pituitary and secreted into the blood stream. TDF targets breast and prostate and induces cell differentiation. However, the mechanism of cell differentiation, the TDF receptor and the TDF pathway have not been adequately investigated. Here, we provide some insights about the possible composition of the TDF-R. TDF-R may be a protei...